5,670 research outputs found

    Women in fisheries: pointers for development

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    Women, Fisheries, Participation, Sustainability, Poverty, Development projects, Fishery technology

    Metabolism of Butoxyethanol in excised human skin in vitro

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    Glycol ethers are widely used in industrial and household applications because their chemical and physical properties make them versatile solvents, miscible with both water and organic media. Due to the ease with which the glycol ethers are absorbed through the skin and the potential for development of adverse health effects it is important to understand the extent to which local metabolism can contribute to local and systemic toxicity. Sections of previously frozen, full thickness excised human skin samples were placed on transwell supports and placed with the underside of the skin in contact with receptor fluid. The skin surface was dosed with 115.2 mg of neat butoxyethanol and the absorption and metabolism of butoxyethanol to butoxyacetic acid monitored over time. In total 64.94 ± 0.04 mg of butoxyethanol or its metabolites were removed from the surface of the skin at 24 hours, representing the equivalent of 56% of the applied dose, the equivalent of 17.5% of the applied dose was recovered from the receiver fluid, 3% from within the skin and the remaining 23.5% of the dose was lost to the atmosphere through evaporation. After 24 hours a total of 31.5 Όg of butoxyacetic acid had been produced representing approximately 0.03% of the applied dose. Therefore approximately 0.16% (31.5 Όg as a percentage of the total amount of butoxyethanol reaching the receiver fluid (20.17 mg) of the absorbed butoxyethanol was metabolised to butoxyacetic acid during its passage through the skin. This suggested that, although enzyme activities capable of converting butoxyethanol to butoxyacetic acid are present in skin, metabolic conversion during percutaneous absorption was small and systemic exposure to the parent compound rather than the metabolite would occur following dermal exposure to butoxyethanol. This experiment demonstrates that it is possible to maintain metabolic activity in skin samples in an in vitro set up for short, but experimentally useful, period.Peer reviewe

    The influence of water mixtures on the dermal absorption of glycol ethers

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    Original article can be found at: http://www.sciencedirect.com/science/journal/0041008X Copyright Elsevier Inc. DOI: 10.1016/j.taap.2006.09.019Glycol ethers are solvents widely used alone and as mixtures in industrial and household products. Some glycol ethers have been shown to have a range of toxic effects in humans following absorption and metabolism to their aldehyde and acid metabolites. This study assessed the influence of water mixtures on the dermal absorption of butoxyethanol and ethoxyethanol in vitro through human skin. Butoxyethanol penetrated human skin up to sixfold more rapidly from aqueous solution (50%, 450 mg/ml) than from the neat solvent. Similarly penetration of ethoxyethanol was increased threefold in the presence of water (50%, 697 mg/ml). There was a corresponding increase in apparent permeability coefficient as the glycol ether concentration in water decreased. The maximum penetration rate of water also increased in the presence of both glycol ethers. Absorption through a synthetic membrane obeyed Fick's Law and absorption through rat skin showed a similar profile to human skin but with a lesser effect. The mechanisms for this phenomenon involves disruption of the stratum corneum lipid bilayer by desiccation by neat glycol ether micelles, hydration with water mixtures and the physicochemical properties of the glycol ether–water mixtures. Full elucidation of the profile of absorption of glycol ethers from mixtures is required for risk assessment of dermal exposure. This work supports the view that risk assessments for dermal contact scenarios should ideally be based on absorption data obtained for the relevant formulation or mixture and exposure scenario and that absorption derived from permeability coefficients may be inappropriate for water-miscible solvents.Peer reviewe

    WP 96 - An overview of women's work and employment in Belarus

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    *Management Summary* This report provides information on Belarus on behalf of the implementation of the DECISIONS FOR LIFE project in that country. The DECISIONS FOR LIFE project aims to raise awareness amongst young female workers about their employment opportunities and career possibilities, family building and the work-family balance. This report is part of the Inventories, to be made by the University of Amsterdam, for all 14 countries involved. It focuses on a gender analysis of work and employment. History (2.1.1). Belarus, severely hit by the German occupation, after the second 1945 emerged as emerged as one of the major manufacturing centres of the Soviet. It suffered heavily from the Chernobyl disaster. After the collapse of the Soviet Union, from 1994 on under president Lukashenko the country kept a command economy, though central planning disappeared. Its growth rates have been considerably throughout the 2000s, though the economy continues to be dependent on heavy discounts in oil and natural gas prices from Russia. Governance (2.1.2). Belarus is a republic with power concentrated in the presidency. The government’s human rights record remains very poor. The judiciary is not independent. Corruption continued to be a problem. Authorities harassed independent trade unions and dismissed their members. Women’s participation in politics and governance is low, except for the Chamber of Representatives. The law protects women well within the family context and protects the physical integrity of women to a relatively high degree. Prospects (2.1.3). Belarus’s economy has been moderately hit by the global economic crisis. The government had to accept loans from the IMF, Russia and China. It undertook some steps to open up the country for foreign investors. In 2009, the country’s GDP fell slightly and real wages by 1 to 5%. Energy-intensive and inefficient production may become the largest hindrance for recovery. Communication (2.2). The coverage of fixed telephone connections has recently increased, but coverage of cellular telephone connections is with over 0.9 cell phones per inhabitant much higher. By 2008, the share Internet users was with 321 per 1,000 of the population rather high, but the government is growingly restricting access to the Internet. Nearly all households have a TV set. The government censored the media and repeatedly harassed and arrested independent journalists The sectoral labour market structure (2.3.1). The sectoral labour market structure is difficult to trace. State employees constitute about 80% of the working population. With nearly 68%, women’s Labour Participation Rate (LPR) in 2008 was 91% of men’s. Official unemployment is low and decreasing, in particular for women. Since 1995, considerable wage increases have been allowed in Belarus, largely outpacing increases in labour productivity. Legislation (2.4.1). Belarus has ratified the eight core ILO Labour Conventions. Yet, the Trade Union Law 2000 and presidential decrees contain serious violations of trade union rights. Specific regulations and benefits for women, including maternity benefits and paid leave on childcare, are comparatively good. Labour relations and wage-setting (2.4.2). The independent trade union movement in Belarus is small. The law provides for the right to organize and bargain collectively; however, government authorities and managers of state-owned enterprises routinely interfered with union activities. ILO recommendations to improve the situation are not acted upon. The statutory minimum wage (2.5.1). In December 2009 the monthly minimum wage, set by law, was BYR 229,700, or 23% of the country’s average monthly wage. Inequality and poverty (2.5.2). Directly after independence, inequality and poverty started to increase, but since 2000 the share under the official poverty line fell rapidly till 6% in 2007. However, this poverty line is set quite low, and depending on other yardsticks poverty in 2007 is estimated at 13 to 43%. Income inequality developed simultaneously with poverty, and is currently at low-to-medium level in international perspective. Population and fertility (2.6.1). Since the 1980s Belarus is in a demographic crisis, with reduced fertility rates and high death. Between 1999 and 2009 the population decreased by over 6%. The total fertility rate, less than 1.3 children per woman, is quite low; the adolescent fertility rate is with 22 per 1,000 low. Health (2.6.2). In 2007 there were an estimated 13,000 persons with HIV/AIDS in Belarus, which is below the regional level. The levels of public awareness of HIV/AIDS seem rather low. The life expectancy at birth for women is recently increasing. The Belarusian health care system aims to provide the entire population with universal access to care and health care benefits are extensive. Women’s labour market share (2.6.3). Women make up half of the country’s labour force. In 2009 women made up majorities in wholesale and retail, restaurants and hotels, education, and public administration et cetera, and in the occupational groups professionals and clerks. At the level of legislators, senior officials and managers, the female share of 45% is high in international perspective. Literacy (2.7.1). The adult literacy rate –-those age 15 and over that can read and write—in 1999-2006 was 98.9%, with hardly a gender gap: 99.0% for men and 98.8% for women. In 2007 the literacy rate for 15-24-year-olds stood at 99.8% for females and 99.7% for males. Education of girls (2.7.2). In 2006, the combined gross enrollment rate in education was nearly 100%, divided in 99% for females and 100% for males. Net enrollment in primary education was for 2005 set at 87.9% for girls and 90.8% for boys. In 2007 women to men parity in secondary education was 102%. With 45% gross enrollment in tertiary education in 2007 and women to men parity reaching 141%, women’s participation at this level of education is high. Female skill levels (2.7.3). Women in the employed population have on average a slightly higher educational level than their male colleagues. More women employed are educated at tertiary level, with women to parity at 118%. We estimate the current size of the target group of DECISIONS FOR LIFE for Ukraine at about 95,000 girls and young women 15-29 of age working in urban areas in (the Belarusian equivalent of) commercial services. Wages (2.8.1). We found for 2008 a considerable gender pay gap, totaling 25%. The pay gap seems to have grown in particular between 1996 and 2004. Women in Belarus have profited considerably less than men from their better education. Moreover, horizontal segregation has taken place with women leaving well-paid sub-sectors of manufacturing like the ICT sector , while many of them entered low-wage jobs like in education and health. The “glass ceiling“ obviously widely remains in place. Working conditions (2.8.2). Especially men in heavy manufacturing still seem often exposed to bad health and safety conditions, though the incidence of reported occupational injuries and casualities is rapidly decreasing. Unfortunately, working hours cannot be detailed by industry and gender.

    A roadmap for the future for fisheries and conservation

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    Fishery management, Marine fisheries, Coastal fisheries, Resource conservation

    A ‘healthy baby’: The double imperative of preimplantation genetic diagnosis

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    This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2010 The Authors.This article reports from a study exploring the social processes, meanings and institutions that frame and produce ‘ethical problems’ and clinical dilemmas for practitioners, scientists and others working in the specialty of preimplantation genetic diagnosis (PGD). A major topic in the data was that, in contrast to IVF, the aim of PGD is to transfer to the woman’s womb only those embryos likely to be unaffected by serious genetic disorders; that is, to produce ‘healthy babies’. Staff described the complex processes through which embryos in each treatment cycle must meet a double imperative: they must be judged viable by embryologists and ‘unaffected’ by geneticists. In this article, we focus on some of the ethical, social and occupational issues for staff ensuing from PGD’s double imperative.The Wellcome Trus

    International Symposium on Women in Asian Fisheries

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    International Symposium on Women in Asian Fisheries presents a record of the 1998 symposium. The fisheries sector has unique problems related to women, which have to be addressed not only from a technical standpoint but also from a social one. The symposium is aimed at stimulating discussion and promoting well-planned research and development activities in this area.Role of Women, Fisheries, Socioeconomics, Indochina, Mekong River, Philippines, Malaysia, Taiwan, India, Bangladesh, Asia,

    Southern Hemisphere automated supernova search

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    The Perth Astronomy Research Group has developed an automated supernova search program, using the 61 cm Perth–Lowell reflecting telescope at Perth Observatory in Western Australia, equipped with a CCD camera. The system is currently capable of observing about 15 objects per hour, using 3 min exposures, and has a detection threshold of 18th–19th magnitude. The entire system has been constructed using low‐cost IBM‐compatible computers. Two original discoveries (SN 1993K, SN 1994R) have so far been made during automated search runs. This paper describes the hardware and software used for the supernova search program, and shows some preliminary results from the search system
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